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Abstract Background Cancer progression reconstruction is an important development stemming from the phylogenetics field. In this context, the reconstruction of the phylogeny representing the evolutionary history presents some peculiar aspects that depend on the technology used to obtain the data to analyze: Single Cell DNA Sequencing data have great specificity, but are affected by moderate false negative and missing value rates. Moreover, there has been some recent evidence of back mutations in cancer: this phenomenon is currently widely ignored. Results We present a new tool, , that reconstructs a tumor phylogeny from Single Cell Sequencing data, allowing each mutation to be lost at most a fixed number of times. The General Parsimony Phylogeny from Single cell () tool is open source and available at https://github.com/AlgoLab/gpps . Conclusions provides new insights to the analysis of intra-tumor heterogeneity by proposing a new progression model to the field of cancer phylogeny reconstruction on Single Cell data. 

Results are presented from two dye release experiments conducted in the seasonal thermocline of the Sargasso Sea, one in a region of low horizontal strain rate (~10−6 s−1), the second in a region of intermediate horizontal strain rate (~10−5 s−1). Both experiments lasted ~6 days, covering spatial scales of 1–10 and 1–50 km for the low and intermediate strain rate regimes, respectively. Diapycnal diffusivities estimated from the two experiments were κz = (2–5) × 10−6 m2 s−1, while isopycnal diffusivities were κH = (0.2–3) m2 s−1, with the range in κH being less a reflection of site-to-site variability, and more due to uncertainties in the background strain rate acting on the patch combined with uncertain time dependence. The Site I (low strain) experiment exhibited minimal stretching, elongating to approximately 10 km over 6 days while maintaining a width of ~5 km, and with a notable vertical tilt in the meridional direction. By contrast, the Site II (intermediate strain) experiment exhibited significant stretching, elongating to more than 50 km in length and advecting more than 150 km while still maintaining a width of order 3–5 km. Early surveys from both experiments showed patchy distributions indicative of small-scale stirring at scales of order a few hundred meters. Later surveys show relatively smooth, coherent distributions with only occasional patchiness, suggestive of a diffusive rather than stirring process at the scales of the now larger patches. Together the two experiments provide important clues as to the rates and underlying processes driving diapycnal and isopycnal mixing at these scales.

 

A bstract We report on a measurement of the $$ {\Lambda}_c^{+} $$ Λ c + to D 0 production ratio in peripheral PbPb collisions at $$ \sqrt{s_{\textrm{NN}}} $$ s NN = 5 . 02 TeV with the LHCb detector in the forward rapidity region 2 < y < 4 . 5. The $$ {\Lambda}_c^{+} $$ Λ c + ( D 0 ) hadrons are reconstructed via the decay channel $$ {\Lambda}_c^{+} $$ Λ c + → pK − π + ( D 0 → K − π + ) for 2 < p T < 8 GeV/ c and in the centrality range of about 65–90%. The results show no significant dependence on p T , y or the mean number of participating nucleons. They are also consistent with similar measurements obtained by the LHCb collaboration in pPb and Pbp collisions at $$ \sqrt{s_{\textrm{NN}}} $$ s NN = 5 . 02 TeV. The data agree well with predictions from PYTHIA in pp collisions at $$ \sqrt{s} $$ s = 5 TeV but are in tension with predictions of the Statistical Hadronization model. 

A bstract A search for the lepton-flavour violating decays B 0 → K *0 μ ± e ∓ and $$ {B}_s^0 $$ B s 0 → ϕμ ± e ∓ is presented, using proton-proton collision data collected by the LHCb detector at the LHC, corresponding to an integrated luminosity of 9 fb − 1 . No significant signals are observed and upper limits of $$ {\displaystyle \begin{array}{c}\mathcal{B}\left({B}^0\to {K}^{\ast 0}{\mu}^{+}{e}^{-}\right)<5.7\times {10}^{-9}\left(6.9\times {10}^{-9}\right),\\ {}\mathcal{B}\left({B}^0\to {K}^{\ast 0}{\mu}^{-}{e}^{+}\right)<6.8\times {10}^{-9}\left(7.9\times {10}^{-9}\right),\\ {}\mathcal{B}\left({B}^0\to {K}^{\ast 0}{\mu}^{\pm }{e}^{\mp}\right)<10.1\times {10}^{-9}\left(11.7\times {10}^{-9}\right),\\ {}\mathcal{B}\left({B}_s^0\to \phi {\mu}^{\pm }{e}^{\mp}\right)<16.0\times {10}^{-9}\left(19.8\times {10}^{-9}\right)\end{array}} $$ B B 0 → K ∗ 0 μ + e − < 5.7 × 10 − 9 6.9 × 10 − 9 , B B 0 → K ∗ 0 μ − e + < 6.8 × 10 − 9 7.9 × 10 − 9 , B B 0 → K ∗ 0 μ ± e ∓ < 10.1 × 10 − 9 11.7 × 10 − 9 , B B s 0 → ϕ μ ± e ∓ < 16.0 × 10 − 9 19.8 × 10 − 9 are set at 90% (95%) confidence level. These results constitute the world’s most stringent limits to date, with the limit on the decay $$ {B}_s^0 $$ B s 0 → ϕμ ± e ∓ the first being set. In addition, limits are reported for scalar and left-handed lepton-flavour violating New Physics scenarios. 

A bstract A first search for the lepton-flavour violating decays B 0 → K *0 τ ± μ ∓ is presented. The analysis is performed using a sample of proton-proton collision data, collected with the LHCb detector at centre-of-mass energies of 7, 8 and 13 TeV between 2011 and 2018, corresponding to an integrated luminosity of 9 fb − 1 . No significant signal is observed, and upper limits on the branching fractions are determined to be $$ \mathcal{B}\left({B}^0\to {K}^{\ast 0}{\tau}^{+}{\mu}^{-}\right)<1.0(1.2)\times {10}^{-5} $$ B B 0 → K ∗ 0 τ + μ − < 1.0 1.2 × 10 − 5 and $$ \mathcal{B}\left({B}^0\to {K}^{\ast 0}{\tau}^{-}{\mu}^{+}\right)<8.2(9.8)\times {10}^{-6} $$ B B 0 → K ∗ 0 τ − μ + < 8.2 9.8 × 10 − 6 at the 90% (95%) confidence level.